The Netherlands Cancer Institute (was established in 1913. The Institute accommodates approximately 550 scientists and scientific support personnel, 53 medical specialists, 180 beds, an out-patient clinic that receives 183,000 patients each year, 5 operating theatres and 9 irradiation units. It is the only dedicated cancer centre in The Netherlands and maintains an important role as a national and international centre of scientific and clinical expertise, development and training.

The three major areas of research are fundamental, clinical and translational cancer research. A thorough understanding of the biological processes of normal cells is the basis for understanding cancerous cells. The laboratory covers all major areas of cancer research, with particular emphasis on cell-based screens, mouse tumour models, cell biology, structural biology and immunotherapy. The institute coordinates and participates in many clinical trials; most of these are phase 1, 2 or 3 studies of potential new treatments such as combinations of targeted therapy, radiotherapy and immunotherapy. Results obtained from fundamental research are translated into clinical applications as the core part of our translation research program.

From its first inception the NKI-AVL saw close collaboration between scientists and clinicians as essential to fighting cancer. Having a laboratory and hospital under one roof in a single independent organization with an open and collaborative atmosphere has led to many important discoveries and improved therapies.